Newly Improved With Added Ingredients

What is ASC III™ Liposome?

ASC III™ Liposome is a suspension of phospholipidic vesicular carriers, in which the external lipophilic wall contains the amphipilic Dipalmitoyl Hydroxyproline (DPHP).
ASC III™ Liposome selectively amplifies the biosynthesis of Collagen III in human skin. ASC III™ Liposome is a unique liposome, which is hexagonally-pyramidal shaped; its membrane always shows angled structures.

INCI Name: Water, Lecithin, Dipalmitoyl Hydroxyproline, Phenoxyethanol, Tall Oil Sterol, Linoleic Acid, Tocopherol, Sodium Ascorbate, Methylparaben, Butylparaben, Ethylparaben, Propylparaben, Mannitol.
 

Product Attributes

• Selectively increases Collagen III production with reduction in Collagenase activity.

• Increase in Collagen production is due to induction of fibroblast activity and not due to fibroblast proliferation

• Pronounced increase in thickness of keratinocyte layers as well as dermal/epidermal junction area. Reformation of collagen fibers in dermis

• Significantly increase skin elasticity.

What happens when we age?

Among the numerous modifications of the extracellular matrix during aging, collagen synthesis shows a significant decrease during the aging process. The ratio of collagen synthesized in skin changes through out life. However, age-related decrease in the ratio of Collagen III / Collagen I is a dramatic one( Peter K. Mays, Jill E. Bishop and Geoffrey J. Laurent, Mechanisms of Aging and Development, 45 (1988). Page 203-212).

The reduction and alteration of the natural collagen support layer that lies beneath the skin cause facial lines and wrinkles. Creams and lotions can moisturize or exfoliate the surface of the skin, but they can't diminish the lines or wrinkles that are caused by the reduction and the alteration of the underlying collagen support.


How does ASC III™ Work?

Figure 3 schematically represents selective stimulation of Collagen III expression in human skin fibroblasts caused by ASC III™ Liposome. In this method, the epidermis is separated from the dermis from a normal human skin sample. The epidermal cells (consisting mainly of keratinocytes) are then incubated in the culture media with ASC III™ Liposome thereby stimulating the production of cytokines. The keratinocyte supernatant culture containing the cytokines is collected, filtered, and then added to the fibroblast cultures. If the keratinocytes were stimulated successfully, they would synthesize cytokines, concomitantly triggering the fibroblasts to produce collagen. Our date shows that ASC III™ Liposome is increasing collagen III synthesis selectively in elderly fibroblasts by similar degrees as in new born cells even though basal levels of collagen synthesis are dependent.


What claim substantiation data do we have?

In-vitro Studies

• Collagen III induction in Fibroblasts – direct Incubation

• Dose/Effect Study of Collagen III induction in Fibroblasts

• Collagen III Induction in Fibroblasts over Time

  • No cytotoxicity

  • No cell proliferation

• Quantitative Determination of Collagen III after Induction of Fibroblasts
   

Ex-vivo Studies

• Effect on Collagen III induction in Excised Human Skin
   

(Immunofluroescence Detection of Collagen III)

• Effect of Skin Smoothness in Excised Human Skin
   

(Image Analysis of Epidermal Surface)

• Increased thickness of human epidermis

• Increased thickness of epidermis & stratum corneum (Histomorphology)
   

In-vivo Studies

• Improvement of Biomechanical Properties of Human Skin (Cutometer Study)

• Improved skin elasticity

• Decreased skin fatigability

• Study of Human Skin after Biopsy

In addition to the ASC III liposome, Ultra Amplifier contains other key ingredients

for a youthful appearance, such as:

Boron Nitride, Safflower Oil, Squalane, Yeast Extract, SOD, Sodium Hyaluronate, Ginseng, Marshmallow Root, St. John's Root, Juniper Oil, Sodium PCA, Tocopherol, Ascorbyl Palmitate and Ascorbic Acid.