Significantly increase skin elasticity.
What happens when we age?
Among the numerous modifications of the extracellular matrix during aging, collagen synthesis shows a significant decrease during the aging process. The ratio of collagen synthesized in skin changes through out life. However, age-related decrease in the ratio of Collagen III / Collagen I is a dramatic one( Peter K. Mays, Jill E. Bishop and Geoffrey J. Laurent, Mechanisms of Aging and Development, 45 (1988). Page 203-212).
The reduction and alteration of the natural collagen support layer that lies beneath the skin cause facial lines and wrinkles. Creams and lotions can moisturize or exfoliate the surface of the skin, but they can't diminish the lines or wrinkles that are caused by the reduction and the alteration of the underlying collagen support.
How does ASC III™ Work?
Figure 3 schematically represents selective stimulation of Collagen III expression in human skin fibroblasts caused by ASC III™ Liposome. In this method, the epidermis is separated from the dermis from a normal human skin sample. The epidermal cells (consisting mainly of keratinocytes) are then incubated in the culture media with ASC III™ Liposome thereby stimulating the production of cytokines. The keratinocyte supernatant culture containing the cytokines is collected, filtered, and then added to the fibroblast cultures. If the keratinocytes were stimulated successfully, they would synthesize cytokines, concomitantly triggering the fibroblasts to produce collagen. Our date shows that ASC III™ Liposome is increasing collagen III synthesis selectively in elderly fibroblasts by similar degrees as in new born cells even though basal levels of collagen synthesis are dependent.
What claim substantiation data do we have?
In-vitro Studies
- Collagen III induction in Fibroblasts – direct Incubation
- Dose/Effect Study of Collagen III induction in Fibroblasts
- Collagen III Induction in Fibroblasts over Time
- No cytotoxicity
- No cell proliferation
- Quantitative Determination of Collagen III after Induction of Fibroblasts
Ex-vivo Studies
- Effect on Collagen III induction in Excised Human Skin
(Immunofluroescence Detection of Collagen III)
- Effect of Skin Smoothness in Excised Human Skin
(Image Analysis of Epidermal Surface)
- Increased thickness of human epidermis
- Increased thickness of epidermis & stratum corneum (Histomorphology)
In-vivo Studies
- Improvement of Biomechanical Properties of Human Skin (Cutometer Study)
- Improved skin elasticity
- Decreased skin fatigability
- Study of Human Skin after Biopsy
All the above studies are the property of Merck KGaA, Darmstadt, Germany
Information on the two new ingredients in Ultra Amplifier.
To our knowledge, Ultra Amplifier is the only product on the market containing all of the following:
5% ASCIII™, Sepitonic M3 (Magnesium Aspartate, Zinc Gluconate, Copper Gluconate), DMAE, Sodium Hyaluronate, Yeast Extract, Sodium PCA, Beta Glucan, Alpha Lipoic Acid, and numerous other ingredients that benefit the skin.
SEPITONIC® M3
SEPITONIC® M3 is a new multi-mineral Chrono-Energiser with COPPER.
Composed by an original association of zinc, copper and magnesium, SEPITONIC® M3 tones and revitalizes chronologically the skin by 'waking up' the cellular metabolism (stimulation of cellular energy budget characterized by an increase of pyruvate, adenosine triphosphate (ATP) and stimulation of general metabolism characterized by an increase of DNA and proteins.
Ideal for tired skin, SEPITONIC® M3 supplies the elements necessary for cell vigor and the maintenance of skin functions. It stimulates cell turnover, restoring vitality and freshness to the skin.
Advantage of Cation combination
Studies performed of this original mixture has demonstrated that there is a synergy between these different compounds. Through its action on the different key steps of the energy cycle, SEPITONIC® M3 has a boosting and stimulating action on cellular defense and repair reactions.
Cations have a proven role in metabolism. Often acting as catalysts in enzyme reactions, they ensure proper operation of metabolic exchanges. SEPITONIC® M3 supplies three important minerals for the skin. For each of them, beneficial actions on the skin can be identified.
Cation - atom or group of atoms carrying a positive charge. The charge results because there are more protons than electrons in the cation.
In addition to the ASC III liposome, Ultra Amplifier contains other key ingredients for a youthful appearance, such as:
Boron Nitride, Safflower Oil, Squalane, Yeast Extract, SOD, Sodium Hyaluronate, Ginseng, Marshmallow Root, St. John's Root, Juniper Oil, Sodium PCA, Tocopherol, Ascorbyl Palmitate and Ascorbic Acid.
It is available in a 1 oz. tube.